RAD23B Antibody

Catalog Number:

47184

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P54727
NCBI Gene ID:5887
Gene Accssion:BC020973

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human RAD23B

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total RAD23B protein.

Applications:

WB, IHC

Background:

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.?

References:

appl_detail:

Western blotting:1:500-2000
Immunofluorescence:1: 20-100

Datasheet PDF