PSEN1 Antibody

Catalog Number:

47180

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P49768
NCBI Gene ID:5663
Gene Accssion:NP_000012

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human PSEN1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PSEN1 protein.

Applications:

WB, IHC

Background:

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

References:

appl_detail:

Western blotting:1:200-1000
Immunofluorescence:1: 20-100

Datasheet PDF