POLG Antibody

Catalog Number:

47178

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P54098
NCBI Gene ID:5428
Gene Accssion:NP_002684

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human POLG

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total POLG protein.

Applications:

IHC

Background:

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.?

References:

appl_detail:

Immunofluorescence:1: 20-100

Datasheet PDF