NARF Antibody

Catalog Number:

47161

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9UHQ1
NCBI Gene ID:26502
Gene Accssion:BC016440

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human NARF

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total NARF protein.

Applications:

IHC

Background:

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.?

References:

appl_detail:

Immunofluorescence:1: 40-200

Datasheet PDF