ITM2B Antibody

Catalog Number:

47141

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9Y287
NCBI Gene ID:9445
Gene Accssion:BC000554

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human ITM2B

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ITM2B protein.

Applications:

WB, IHC

Background:

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

References:

appl_detail:

Western blotting:1:500-2000
Immunofluorescence:1: 20-100

Datasheet PDF