GCDH Antibody

Catalog Number:

47125

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q92947
NCBI Gene ID:2639
Gene Accssion:BC002579

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human GCDH

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total GCDH protein.

Applications:

IHC

Background:

The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12.

References:

appl_detail:

Immunofluorescence:1: 20-100

Datasheet PDF