ELANE Antibody

Catalog Number:

47101

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P08246
NCBI Gene ID:1991
Gene Accssion:NP_001963

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human ELANE

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ELANE protein.

Applications:

IHC

Background:

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.

References:

appl_detail:

Immunofluorescence:1: 20-100

Datasheet PDF