EFCAB5 Antibody

Catalog Number:

47093

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:A4FU69
NCBI Gene ID:374786
Gene Accssion:NP_940931

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human EFCAB5

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total EFCAB5 protein.

Applications:

IHC

Background:

EF-CAB5(EF-hand calcium-binding domain-containing protein 5) is a 1,503 amino acid protein containing one EF-hand domain. Existing as four alternatively spliced isoforms, the gene encoding EF-CAB5 maps to human chromosome 17q11.2. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and LiFraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

References:

appl_detail:

Immunofluorescence:1: 25-100

Datasheet PDF