DUX4 Antibody

Catalog Number:

47085

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9UBX2
NCBI Gene ID:100288687/107987484/107987485/107987486/107987487/107987488/107987489/107987490/107987491
Gene Accssion:NP_001280727

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human DUX4

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DUX4 protein.

Applications:

IHC

Background:

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants.

References:

appl_detail:

Immunofluorescence:1: 20-100

Datasheet PDF