DROSHA Antibody

Catalog Number:

47079

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9NRR4
NCBI Gene ID:29102
Gene Accssion:NP_037367

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human DROSHA

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DROSHA protein.

Applications:

IHC

Background:

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.?

References:

appl_detail:

Immunofluorescence:1: 20-100

Datasheet PDF