DOCK11 Antibody

Catalog Number:

47074

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q5JSL3
NCBI Gene ID:139818
Gene Accssion:NP_653259

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human DOCK11

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DOCK11 protein.

Applications:

IHC

Background:

Small GTPases of the Rho family, Rho, Rac, and Cdc42, are critical regulators of the actin cytoskeleton and many other cellular processes. Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs). DOCK 11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins that is mainly expressed in peripheral blood leukocytes. DOCK 11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP. Cdc42 mediates cell polarity, gene expression, cell cycle progression and cellCcell contacts. Similar to other DOCK family members, DOCK 11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.

References:

appl_detail:

Immunofluorescence:1: 20-100

Datasheet PDF