DMTN Antibody

Catalog Number:

47066

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q08495
NCBI Gene ID:2039
Gene Accssion:NP_001107607

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human DMTN

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DMTN protein.

Applications:

WB, IHC

Background:

The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.?

References:

appl_detail:

Western blotting:1:500-2000
Immunofluorescence:1: 20-100

Datasheet PDF