DIS3 Antibody

Catalog Number:

47056

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9Y2L1
NCBI Gene ID:22894
Gene Accssion:NP_055768

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human DIS3

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DIS3 protein.

Applications:

IHC

Background:

The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3' to 5' exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3' regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events.

References:

appl_detail:

Immunofluorescence:1: 25-100

Datasheet PDF