DEPTOR Antibody

Catalog Number:

47047

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q8TB45
NCBI Gene ID:64798
Gene Accssion:NP_073620

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human DEPTOR

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DEPTOR protein.

Applications:

WB, IHC

Background:

DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

References:

appl_detail:

Western blotting:1:200-1000
Immunofluorescence:1: 20-100

Datasheet PDF