DENND1B Antibody

Catalog Number:

47045

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q6P3S1
NCBI Gene ID:163486
Gene Accssion:BC022561

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human DENND1B

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DENND1B protein.

Applications:

IHC

Background:

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).

References:

appl_detail:

Immunofluorescence:1: 20-100

Datasheet PDF