DDHD1 Antibody

Catalog Number:

47033

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q8NEL9
NCBI Gene ID:80821
Gene Accssion:NP_001153620

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human DDHD1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DDHD1 protein.

Applications:

WB, IHC

Background:

This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms.

References:

appl_detail:

Western blotting:1:200-1000
Immunofluorescence:1: 20-100

Datasheet PDF