DAGLB Antibody

Catalog Number:

47015

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q8NCG7
NCBI Gene ID:221955
Gene Accssion:NP_631918

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human DAGLB

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DAGLB protein.

Applications:

IHC

Background:

Members of the AB hydrolase superfamily have diverse catalytic functions and play a crucial role in the metabolism of lipids. DAGLβ (diacylglycerol lipase beta), also known as KCCR13L, is a 672 amino acid multi-pass membrane protein that belongs to the AB hydrolase superfamily. DAGLβ uses calcium as a cofactor to catalyze the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), a reaction that is required for axonal growth and for retrograde synaptic signaling at mature synapses. DAGLβ functions at an optimal pH of 7 and its activity is inhibited by p-hydroxy-mercuri-benzoate and HgCl2, but not PMSF. There are three isoforms of DAGLβ that are produced as a result of alternative splicing events.

References:

appl_detail:

Immunofluorescence:1: 20-100

Datasheet PDF