DAGLA Antibody

Catalog Number:

47014

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9Y4D2
NCBI Gene ID:747
Gene Accssion:NP_006124

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human DAGLA

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DAGLA protein.

Applications:

IHC

Background:

Members of the AB hydrolase superfamily have diverse catalytic functions and play a crucial role in the metabolism of lipids. DAGLα (diacylglycerol lipase alpha), also known as NSDDR or C11orf11, is a 1,042 amino acid multi-pass membrane protein that belongs to the AB hydrolase superfamily. Highly expressed in brain and pancreas, DAGLα uses calcium as a cofactor to catalyze the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), a reaction that is required for axonal growth and for retrograde synaptic signaling at mature synapses. DAGLα functions as at optimal pH of 7 and its activity is inhibited by p-hydroxy-mercuri-benzoate and HgCl2. The gene encoding DAGLα maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome.

References:

appl_detail:

Immunofluorescence:1: 25-100

Datasheet PDF