CCP110 Antibody

Catalog Number:

46945

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:O43303
NCBI Gene ID:9738
Gene Accssion:NP_055526

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human CCP110

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CCP110 protein.

Applications:

IHC

Background:

Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545?PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).

References:

appl_detail:

Immunofluorescence:1: 20-100

Datasheet PDF