RFX6 Antibody

Catalog Number:

47324

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q8HWS3
NCBI Gene ID:222546
Gene Accssion:BC039248

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human RFX6

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total RFX6 protein.

Applications:

IHC

Background:

The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.

References:

appl_detail:

IHC dilution:1: 40-200

Datasheet PDF