CNOT10 Antibody

Catalog Number:

46960

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9H9A5
NCBI Gene ID:25904
Gene Accssion:BC002931

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human CNOT10

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CNOT10 protein.

Applications:

IHC

Background:

CNOT10 is a subunit of the CCR4-NOT complex which consists of at least five other CNOT subunit proteins and TAB182. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription, as well as in mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are uniquely involved in influencing nuclear hormone receptor activities. In effect, this complex has an important role as a transcription regulator and repressor of nuclear receptor signaling that is relevant to the molecular pathways involved in cancer. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome.

References:

appl_detail:

Immunofluorescence:1: 20-100

Datasheet PDF