YTHDF1 Antibody

Catalog Number:

46714

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9BYJ9
NCBI Gene ID:54915
NCBI Protein:NP_060268

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human YTHDF1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total YTHDF1 protein.

Applications:

IHC

Background:

YTHDF1, also designated Dermatomyositis associated with cancer putative autoantigen 1 (DACA-1), is a 559 amino acid protein that contains one YTH domain, which is a potential RNA binding domain.?Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440).

References:

appl_detail:

Immunohistochemistry: 1: 40-200

Datasheet PDF