UNC45B Antibody

Catalog Number:

46695

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8IWX7
NCBI Gene ID:146862
NCBI Protein:BC101063

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human UNC45B

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total UNC45B protein.

Applications:

WB

Background:

This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

Western blotting: 1:500-1:2000

Datasheet PDF