TNFSF8 Antibody

Catalog Number:

46687

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P32971
NCBI Gene ID:944
NCBI Protein:NP_001235

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human TNFSF8

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total TNFSF8 protein.

Applications:

IHC

Background:

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Immunohistochemistry: 1: 25-100

Datasheet PDF