THOC6 Antibody

Catalog Number:

46683

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q86W42
NCBI Gene ID:79228
NCBI Protein:NP_077315

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human THOC6

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total THOC6 protein.

Applications:

IHC

Background:

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.

References:

appl_detail:

Immunohistochemistry: 1: 25-100

Datasheet PDF