SPRTN Antibody

Catalog Number:

46677

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9H040
NCBI Gene ID:83932
NCBI Protein:BC015740

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the N terminal of human SPRTN

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total SPRTN protein.

Applications:

IHC

Background:

The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified.

References:

appl_detail:

Immunohistochemistry: 1: 50-300

Datasheet PDF