SLC25A27 Antibody

Catalog Number:

46669

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O95847
NCBI Gene ID:9481
NCBI Protein:NP_004268

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human SLC25A27

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total SLC25A27 protein.

Applications:

IHC

Background:

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF