SEMA4D Antibody

Catalog Number:

46665

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q92854
NCBI Gene ID:10507
NCBI Protein:BC054500

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to internal residues of human SEMA4D

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total SEMA4D protein.

Applications:

IHC

Background:

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.

References:

appl_detail:

Immunohistochemistry: 1: 50-300

Datasheet PDF