USP12 Antibody

Catalog Number:

46696

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O75317
NCBI Gene ID:219333
NCBI Protein:BC026072

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Full length fusion protein of human USP12

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total USP12 protein.

Applications:

WB IHC

Background:

The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP12 (ubiquitin specific peptidase 12), also known as UBH1 or USP12L1, is a 370 amino acid protein belonging to the peptidase C19 family and the USP12/USP46 subfamily. Considered a deubiquitinating enzyme, it is suggested that USP12 has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have high activity. The gene encoding USP12 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1: 25-100

Datasheet PDF