RBL2 Antibody

Catalog Number:

46651

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q08999
NCBI Gene ID:5934
NCBI Protein:NP_005602

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human RBL2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total RBL2 protein.

Applications:

IHC

Background:

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

References:

appl_detail:

Immunohistochemistry: 1: 30-150

Datasheet PDF