PRMT6 Antibody

Catalog Number:

46648

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q96LA8
NCBI Gene ID:55170
NCBI Protein:NP_060607

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human PRMT6

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PRMT6 protein.

Applications:

WB IHC

Background:

The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1: 20-100

Datasheet PDF