PNPO Antibody

Catalog Number:

46643

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9NVS9
NCBI Gene ID:55163
NCBI Protein:NP_060599

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human PNPO

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PNPO protein.

Applications:

IHC

Background:

The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF