PHF21A Antibody

Catalog Number:

46640

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q96BD5
NCBI Gene ID:51317
NCBI Protein:BC015714

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human PHF21A

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PHF21A protein.

Applications:

WB IHC

Background:

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1: 40-200

Datasheet PDF