PFKFB4 Antibody

Catalog Number:

46639

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q16877
NCBI Gene ID:5210
NCBI Protein:NP_004558

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human PFKFB4

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PFKFB4 protein.

Applications:

WB

Background:

The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Western blotting: 1:200-1:1000

Datasheet PDF