OTUD7B Antibody

Catalog Number:

46637

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q6GQQ9
NCBI Gene ID:56957
NCBI Protein:NP_064590

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human OTUD7B

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total OTUD7B protein.

Applications:

IHC

Background:

OTUD7B (OTU domain-containing protein 7B), also known as ZA20D1 or Cezanne, is an 843 amino acid protein that localizes to both the nucleus and the cytoplasm. Expressed in a variety of tissues, including liver, kidney, heart and immature B-cells, OTUD7B functions to hydrolyze branched and linear forms of polyubiquitin, specifically deubiquinating Lys-48- and Lys-63-linked polyubiquitin chains. Via its ability to deubiquinate target proteins, OTUD7B regulates the inflammatory response within the cell and may play a role in cell survival. More specifically, OTUD7B forms a negative feedback loop in pro-inflammatory signaling, thereby suppressing NF?B activity and helping to resolve inflammatory responses. OTUD7B contains one C-terminal A20-type zinc finger, one OTU domain and one N-terminal TRAF-binding domain through which it conveys its deubiquitinating activity.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF