MTA2 Antibody

Catalog Number:

46616

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O94776
NCBI Gene ID:9219
NCBI Protein:NP_004730

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human MTA2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total MTA2 protein.

Applications:

WB IHC

Background:

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1: 25-100

Datasheet PDF