MORF4L2 Antibody

Catalog Number:

46614

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q15014
NCBI Gene ID:9643
NCBI Protein:NP_036418

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human MORF4L2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total MORF4L2 protein.

Applications:

WB IHC

Background:

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1: 25-100

Datasheet PDF