MBD2-b Antibody

Catalog Number:

46610

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9UBB5
NCBI Gene ID:8932
NCBI Protein:NP_056647

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human MBD2-b

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total MBD2-b protein.

Applications:

IHC

Background:

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF