MB21D1 Antibody

Catalog Number:

46608

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8N884
NCBI Gene ID:115004
NCBI Protein:NP_612450

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human MB21D1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total MB21D1 protein.

Applications:

IHC

Background:

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF