LDLR Antibody

Catalog Number:

46597

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P01130
NCBI Gene ID:3949
NCBI Protein:NP_000518

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human LDLR

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total LDLR protein.

Applications:

IHC

Background:

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

References:

appl_detail:

Immunohistochemistry: 1: 25-100

Datasheet PDF