KLHL12 Antibody

Catalog Number:

46592

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q53G59
NCBI Gene ID:59349
NCBI Protein:BC003183

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human KLHL12

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total KLHL12 protein.

Applications:

IHC

Background:

This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

Immunohistochemistry: 1: 20-100

Datasheet PDF