KLF2 Antibody

Catalog Number:

46591

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9Y5W3
NCBI Gene ID:10365
NCBI Protein:NP_057354

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human KLF2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total KLF2 protein.

Applications:

WB

Background:

The kr¨¹ppel-type zinc finger transcription factors comprise a conserved family of DNA binding proteins that are important in developmental regulation. The kr¨¹ppel zinc finger transcription factor was initially identified in Drosophila as a segmentation gene. Kr¨¹ppel-like factors that have been characterized in mammals include erythroid kr¨¹ppel-like transcription factor (EKLF), lung kr¨¹ppel-like transcription factor (LKLF) and gut kr¨¹ppel-like transcription factor (GKLF). EKLF is expressed principally in erythroid tissues, and LKLF expression is limited to the lung. GKLF is found predominantly in gut and has been shown to be expressed during growth arrest. In a developing mouse embryo, LKLF is necessary for normal tunica media formation and blood vessel stabilization. LKLF is also sufficient to program quiescence in T cells by negatively regulating the c-Myc-dependent pathway. The gene for human LKLF maps to chromosome 19p13.11.

References:

appl_detail:

Western blotting: 1:200-1:1000

Datasheet PDF