HIPK3 Antibody

Catalog Number:

46575

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9H422
NCBI Gene ID:10114
NCBI Protein:NP_001041665

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to internal residues of human HIPK3

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total HIPK3 protein.

Applications:

IHC

Background:

Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

References:

appl_detail:

Immunohistochemistry: 1: 50-300

Datasheet PDF