FAM175A Antibody

Catalog Number:

46563

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q6UWZ7
NCBI Gene ID:84142
NCBI Protein:BC016905

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Full length fusion protein of human FAM175A

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total FAM175A protein.

Applications:

IHC

Background:

Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

References:

appl_detail:

Immunohistochemistry: 1: 25-100

Datasheet PDF