COL25A1 Antibody

Catalog Number:

46532

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9BXS0
NCBI Gene ID:84570
NCBI Protein:NP_942014

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human COL25A1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total COL25A1 protein.

Applications:

WB IHC

Background:

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1: 30-150

Datasheet PDF