COA7 Antibody

Catalog Number:

46530

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q96BR5
NCBI Gene ID:65260
NCBI Protein:BC015313

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Full length fusion protein of human COA7

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total COA7 protein.

Applications:

WB IHC

Background:

The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water. COA7 (cytochrome c oxidase assembly factor 7), also known as RESA1, SELRC1 or C1orf163, is a 231 amino acid mitochondrial protein that belongs to the hcp beta-lactamase family. Consisting of five Sel1-like repeats, COA7 may be associated with respiratory chain assembly. COA7 is encoded by a gene located on human chromosome 1p32.3. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene, which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1: 40-200

Datasheet PDF