CHIT1 Antibody

Catalog Number:

46490

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q13231
NCBI Gene ID:1118
NCBI Protein:BC103695

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human CHIT1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CHIT1 protein.

Applications:

WB IHC

Background:

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1: 25-100

Datasheet PDF