CEP57 Antibody

Catalog Number:

46476

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q86XR8
NCBI Gene ID:9702
NCBI Protein:BC039711

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the N terminal of human CEP57

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CEP57 protein.

Applications:

WB IHC

Background:

This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1: 25-100

Datasheet PDF