CEP290 Antibody

Catalog Number:

46475

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O15078
NCBI Gene ID:80184
NCBI Protein:BC008641

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to internal residues of human CEP290

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CEP290 protein.

Applications:

IHC

Background:

This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.

References:

appl_detail:

Immunohistochemistry: 1: 25-100

Datasheet PDF