CDC45 Antibody

Catalog Number:

46445

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O75419
NCBI Gene ID:8318
NCBI Protein:BC006232

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic protein corresponding to residues near the C terminal of human CDC45

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CDC45 protein.

Applications:

IHC

Background:

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants.

References:

appl_detail:

Immunohistochemistry: 1: 30-150

Datasheet PDF